Kinases相关论文
NLRP3是位于细胞质中的模式识别受体,属于NOD样受体家族.在多种危险相关分子模式和病原体相关分子模式的激活下,NLRP3受体通过招募......
Background:In mammalian meiosis,the X and Y chromosomes are largely unsynapsed and transcriptionally silenced during the......
Cancer metastasis accounts for over 90% of cancer death.However, its mechanisms are still poorly understood and the curr......
Leaf erectness is a key to determine plant architecture and yield, particularly in cereal crops....
目的:肿瘤的发生与发展都与肿瘤血管生成密切相关。肿瘤血管生成是一个复杂的过程,由多种促血管生成和抗血管生成因素共同调节。血......
肿瘤发生是一个多步骤过程.绝大多数人肿瘤由产生了系列相继变化的单一细胞形成.这些变化导致细胞有丝分裂信号或生长控制的细微异......
目的：研究酪氨酸激酶是否参与α１Ａ肾上腺素受体引起血管平滑肌收缩的信号传导．方法：灌流大鼠后肢血管床标本，观察酪氨酸激酶抑制剂对去......
Effects of MEK inhibitor U0126 on meiotic progression in mouse oocytes:microtuble organization, asym
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Effects of MEK inhibitor U0126 on meiotic progression in mouse oocytes:microtuble organization, asym
In this study we used U0126, a potent and specific inhibitor of MEK, to study the roles of MEK/ERK/p90rsk signaling path......
In this paper, based on the known crystal structures of Square Pyramid (SP) and Trigonal Bipyramid (TBP) penta-coordinat......
Objective:To investigate to the expression effect of hypoxia and hypoxia/reoxygenation on ROS,MAPKs and cell apoptosis i......
Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic c
Objective:Pancreatic ductal adenocarcinoma(PDAC)is a deadly malignancy,due in large part to its resistance to convention......
Identification of Secondary Structure of Extracellular Signal Regulated Kinase (ERK) Interacting Pro
ERK is involved in multiple cell signaling pathways through its interacting proteins. By </span><i><span style="font-siz......
蛋白激酶，特别是丝裂原活化蛋白激酶（mitogen-activated protein kinases，MAPKs）和受体酪氨酸激酶（receptor-tyrosine kinases，RTKs）通过......
Aurora kinases regulate multiple steps of mitotic cell division in eukaryotic cells. Overexpression of aurora kinases ha......
Molecularly targeted therapeutic agents are constantly being developed and have been shown to be effective in various cl......
Characterization of the antiviral effects of interferon-α against a SARS-like coronoavirus infection
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目的：研究卵巢恶性肿瘤组织中Aurora-Ipl1激酶1(AIK1)mRNA的表达，探讨AIK1基因与卵巢肿瘤发生的关系。方法：采用半定量逆转录聚合酶链......
EphA2是一个跨膜酪氨酸激酶受体，属于酪氨酸激酶受体（receptor tyrosine kinases，RTKs）超家族成员之一。EphA2通常以相对较低的水平表......
AIM:To investigate lipopolysaccharide(LPS) related signal transduction in interstitial cells of Cajal(ICCs) from mouse s......
P21-activated kinases （PAKs） are central players invarious oncogenic signaling pathways. The six PAKfamily members are cla......
Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an
AIM To investigate the antioxidant effect of caffeic acid phenethyl ester(CAPE) in hepatic stellate cell-T6(HSC-T6) cell......
Protein kinases play an important role in every aspect of cellular life. In this study, we systemically identified prote......
P21活化的蛋白激酶（p21-activated kinases，PAKs）是Rho家族中GTP酶重要效应物，已证实对细胞繁殖和生存有重要意义。研究发现PAKs与神经......
综述AIKs相关激酶在不同物种中的分布,及其在染色体分离及胞质分裂过程中的关键作用....
The mitogen-activated protein kinase(MAPK) interacting protein kinases 1 and 2(Mnk1 and Mnk2) play important roles in co......
The goal of this work is the development of novel peptides with high efficacy of inhibiting activity of CDK6/CyclinD com......
高温是常见的致畸因素之一．对多种哺乳动物包括人类具有致畸作用，但高温致畸机制尚不明确。最近研究发现，高温作为外源性刺激会使胚胎......
Antiviral drugs currently on the market primarily target proteins encoded by specific viruses. The drawback of these dru......
Antiviral drugs currently on the market primarily target proteins encoded by specific viruses. The drawback of these dru......
克隆鉴定了一个水稻促分裂原活化蛋白激酶（mitogen-activated protein kinases, MAPK）基因OsMPK4．OsMPK4基因cDNA全长1483bp，包含一个1......
“Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinas
Aside from Polo and Aurora, a third but less studied kinase family involved in mitosis regulation is the never in mitosi......
Effects of MEK inhibitor U0126 on meiotic progression in mouse oocytes： microtuble organization, asy
In this study we used U0126, a potent and specific inhibitor of MEK, to study the roles of MEK/ERK/p90rsk signaling path......
The JAK (Janus kinase) family members play a role in the transmission of signals from extracellular stimuli across the p......
2011年第3期《细胞》（＆zz）杂志发表了题为＂Activation of Multiple Proto - oncogenic Tyrosine Kinases in Breast Cancer via Loss o......
Effect of phosphorylation of MAPK and Stat3 and expression of c-fas and c-jun proteins on hepatocarc
AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellu......
p21-activated kinase signalling in pancreatic cancer:New insights into tumour biology and immune mod
Pancreatic cancer is one of the most aggressive and lethal malignancies worldwide,with a very poor prognosis and a five-......
受体酪氨酸激酶（receptor tyrosine kinases，RTK）家族成员Ephs及其配体ephrins在胚胎发育尤其是中枢神经系统的发育中的作用是目前的......
Portal hypertension(PHT)is an important consequence of liver cirrhosis,which can lead to complications that adversely af......
ＲＮＡ剪接和剪接调控桂建芳（中国科学院水生生物研究所武汉４３００７２）基因是遗传的功能单位，蛋白是由基因表达的行使生理功能的主体。７０年代以前，人们对......
Previously, we reported that M-CSF induced monocyte survival through the activation of Akt, p38MAPK and Erk1/2 kinases. ......
A novel transgenic zebrafish sensor for screening of potential therapeutic drug for Parkinson diseas
The sensitive tyrosine hydroxylase-green fluorescent protein （TH-GFP） transgenic zebrafish was originally developed and ap......
